Demonstration of Mutation Development and Virulence Change in Reference Candida Strains Exposed to Caspofungin
نویسندگان
چکیده
Purpose: Echinocandin resistance is causing problems in the treatment. FKS gene mutations were detected on genomes of resistant Candida strains exposed to echinocandins. The aim this study was compare reference caspofungin and investigate whether there a difference virulence factors between non-exposed with caspofungin.
 Methods: Caspofungin susceptible strains, during their incubation containing agar plates at concentrations 16-0.03 µg/ml. MIC values determined all strains. regions sequenced order reveal Relationship exposure properties investigated vivo vitro methodologies. mini-experimental animal model Galleria mellonella (wax moth) performed.
 Results: found be increased as one/two fold dilution when compared sensitive result sequence no mutation while point C. glabrata detected. No significant strains.
 Conclusions: In conclusion, it understood that fact even low caused an increase MIC, drug should evaluated independently.
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ژورنال
عنوان ژورنال: Journal of basic and clinical health sciences
سال: 2021
ISSN: ['2458-8938', '2564-7288']
DOI: https://doi.org/10.30621/jbachs.920675